Structural insights into the catalytic mechanism of the microcystin tailoring enzyme McyI
Abstract The most common cyanotoxin microcystin is a cyclic heptapeptide produced by non-ribosomal peptide-polyketide synthetases and tailoring enzymes.The tailoring enzyme McyI, a 2-hydroxyacid dehydrogenase, converts (3-methyl)malate Digital Picture Frame into (3-methyl)oxaloacetate to produce the non-proteinogenic amino acid (3-methyl)aspartate.